ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease
Identifieur interne : 001413 ( Main/Exploration ); précédent : 001412; suivant : 001414ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease
Auteurs : Liana C. Del Gobbo ; Fumiaki Imamura ; Stella Aslibekyan ; Matti Marklund ; Jyrki K. Virtanen ; Maria Wennberg ; Mohammad Y. Yakoob ; Stephanie E. Chiuve ; Luicito Dela Cruz ; Alexis C. Frazier-Wood ; Amanda M. Fretts ; Eliseo Guallar ; Chisa Matsumoto ; Kiesha Prem ; Tosh Tanaka ; Jason H. Y. Wu ; Xia Zhou ; Catherine Helmer ; Erik Ingelsson ; Jian-Min Yuan ; Pascale Barberger-Gateau ; Hannia Campos ; Paulo H. M. Chaves ; Luc Djoussé ; Graham G. Giles ; Jose G Mez-Aracena ; Allison M. Hodge ; Frank B. Hu ; Jan-H Kan Jansson ; Ingegerd Johansson ; Kay-Tee Khaw ; Woon-Puay Koh ; Rozenn N. Lemaitre ; Lars Lind ; Robert N. Luben ; Eric B. Rimm ; Ulf Risérus ; Cecilia Samieri ; Paul W. Franks ; David S. Siscovick ; Meir Stampfer ; Lyn M. Steffen ; Brian T. Steffen ; Michael Y. Tsai ; Rob M. Van Dam ; Sari Voutilainen ; Walter C. Willett ; Mark Woodward ; Dariush MozaffarianSource :
- JAMA internal medicine [ 2168-6106 ] ; 2016.
Abstract
The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers.
To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5ω-3), docosapentaenoic acid (DPA; 22:5ω-3), and docosahexaenoic acid (DHA; 22:6ω-3) and plant-derived α-linolenic acid (ALA; 18:3ω-3) for incident CHD.
A global consortium of 19 studies identified by November 2014.
Available prospective (cohort, nested case-control) or retrospective studies with circulating or tissue ω-3 biomarkers and ascertained CHD.
Each study conducted standardized, individual-level analysis using harmonized models, exposures, outcomes, and covariates. Findings were centrally pooled using random-effects meta-analysis. Heterogeneity was examined by age, sex, race, diabetes, statins, aspirin, ω-6 levels, and
le;&-1qIncident total CHD, fatal CHD, and nonfatal myocardial infarction (MI).
The 19 studies comprised 16 countries, 45 637 unique individuals, and 7973 total CHD, 2781 fatal CHD, and 7157 nonfatal MI events, with ω-3 measures in total plasma, phospholipids, cholesterol esters, and adipose tissue. Median age at baseline was 59 years (range, 18–97 years), and 28 660 (62.8%) were male. In continuous (per 1-SD increase) multivariable-adjusted analyses, the ω-3 biomarkers ALA, DPA, and DHA were associated with a lower risk of fatal CHD, with relative risks (RRs) of 0.91 (95% CI, 0.84–0.98) for ALA, 0.90 (95% CI, 0.85–0.96) for DPA, and 0.90 (95% CI, 0.84–0.96) for DHA. Although DPA was associated with a lower risk of total CHD (RR, 0.94; 95% CI, 0.90–0.99), ALA (RR, 1.00; 95% CI, 0.95–1.05), EPA (RR, 0.94; 95% CI, 0.87–1.02), and DHA (RR, 0.95; 95% CI, 0.91–1.00)were not. Significant associations with nonfatal MI were not evident per 1 SD. Across quintiles, lower risk of nonfatal MI was evident with EPA (RR, 0.71; 95% CI, 0.56–0.90) and ALA (RR, 0.87; 95% CI, 0.78–0.97), and lower risk of fatal CHD was evident with DPA (RR, 0.76; 95% CI, 0.65–0.90) and DHA (RR, 0.77; 95% CI, 0.64–0.89). Associations appeared generally stronger in phospholipids and total plasma. Restricted cubic splines did not identify evidence of nonlinearity in dose responses.
On the basis of available studies of free-living populations globally, biomarker concentrations of seafood and plant-derived ω-3 fatty acids are associated with a lower incidence of fatal CHD.
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DOI: 10.1001/jamainternmed.2016.2925
PubMed: 27357102
PubMed Central: 5183535
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Del Gobbo</name></author><author><name sortKey="Imamura, Fumiaki" sort="Imamura, Fumiaki" uniqKey="Imamura F" first="Fumiaki" last="Imamura">Fumiaki Imamura</name></author><author><name sortKey="Aslibekyan, Stella" sort="Aslibekyan, Stella" uniqKey="Aslibekyan S" first="Stella" last="Aslibekyan">Stella Aslibekyan</name></author><author><name sortKey="Marklund, Matti" sort="Marklund, Matti" uniqKey="Marklund M" first="Matti" last="Marklund">Matti Marklund</name></author><author><name sortKey="Virtanen, Jyrki K" sort="Virtanen, Jyrki K" uniqKey="Virtanen J" first="Jyrki K." last="Virtanen">Jyrki K. Virtanen</name></author><author><name sortKey="Wennberg, Maria" sort="Wennberg, Maria" uniqKey="Wennberg M" first="Maria" last="Wennberg">Maria Wennberg</name></author><author><name sortKey="Yakoob, Mohammad Y" sort="Yakoob, Mohammad Y" uniqKey="Yakoob M" first="Mohammad Y." last="Yakoob">Mohammad Y. Yakoob</name></author><author><name sortKey="Chiuve, Stephanie E" sort="Chiuve, Stephanie E" uniqKey="Chiuve S" first="Stephanie E." last="Chiuve">Stephanie E. Chiuve</name></author><author><name sortKey="Dela Cruz, Luicito" sort="Dela Cruz, Luicito" uniqKey="Dela Cruz L" first="Luicito" last="Dela Cruz">Luicito Dela Cruz</name></author><author><name sortKey="Frazier Wood, Alexis C" sort="Frazier Wood, Alexis C" uniqKey="Frazier Wood A" first="Alexis C." last="Frazier-Wood">Alexis C. Frazier-Wood</name></author><author><name sortKey="Fretts, Amanda M" sort="Fretts, Amanda M" uniqKey="Fretts A" first="Amanda M." last="Fretts">Amanda M. Fretts</name></author><author><name sortKey="Guallar, Eliseo" sort="Guallar, Eliseo" uniqKey="Guallar E" first="Eliseo" last="Guallar">Eliseo Guallar</name></author><author><name sortKey="Matsumoto, Chisa" sort="Matsumoto, Chisa" uniqKey="Matsumoto C" first="Chisa" last="Matsumoto">Chisa Matsumoto</name></author><author><name sortKey="Prem, Kiesha" sort="Prem, Kiesha" uniqKey="Prem K" first="Kiesha" last="Prem">Kiesha Prem</name></author><author><name sortKey="Tanaka, Tosh" sort="Tanaka, Tosh" uniqKey="Tanaka T" first="Tosh" last="Tanaka">Tosh Tanaka</name></author><author><name sortKey="Wu, Jason H Y" sort="Wu, Jason H Y" uniqKey="Wu J" first="Jason H. Y." last="Wu">Jason H. Y. Wu</name></author><author><name sortKey="Zhou, Xia" sort="Zhou, Xia" uniqKey="Zhou X" first="Xia" last="Zhou">Xia Zhou</name></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name></author><author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name></author><author><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name></author><author><name sortKey="Campos, Hannia" sort="Campos, Hannia" uniqKey="Campos H" first="Hannia" last="Campos">Hannia Campos</name></author><author><name sortKey="Chaves, Paulo H M" sort="Chaves, Paulo H M" uniqKey="Chaves P" first="Paulo H. M." last="Chaves">Paulo H. M. Chaves</name></author><author><name sortKey="Djousse, Luc" sort="Djousse, Luc" uniqKey="Djousse L" first="Luc" last="Djoussé">Luc Djoussé</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="G Mez Aracena, Jose" sort="G Mez Aracena, Jose" uniqKey="G Mez Aracena J" first="Jose" last="G Mez-Aracena">Jose G Mez-Aracena</name></author><author><name sortKey="Hodge, Allison M" sort="Hodge, Allison M" uniqKey="Hodge A" first="Allison M." last="Hodge">Allison M. Hodge</name></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name></author><author><name sortKey="Jansson, Jan H Kan" sort="Jansson, Jan H Kan" uniqKey="Jansson J" first="Jan-H Kan" last="Jansson">Jan-H Kan Jansson</name></author><author><name sortKey="Johansson, Ingegerd" sort="Johansson, Ingegerd" uniqKey="Johansson I" first="Ingegerd" last="Johansson">Ingegerd Johansson</name></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name></author><author><name sortKey="Koh, Woon Puay" sort="Koh, Woon Puay" uniqKey="Koh W" first="Woon-Puay" last="Koh">Woon-Puay Koh</name></author><author><name sortKey="Lemaitre, Rozenn N" sort="Lemaitre, Rozenn N" uniqKey="Lemaitre R" first="Rozenn N." last="Lemaitre">Rozenn N. Lemaitre</name></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name></author><author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name></author><author><name sortKey="Rimm, Eric B" sort="Rimm, Eric B" uniqKey="Rimm E" first="Eric B." last="Rimm">Eric B. Rimm</name></author><author><name sortKey="Riserus, Ulf" sort="Riserus, Ulf" uniqKey="Riserus U" first="Ulf" last="Risérus">Ulf Risérus</name></author><author><name sortKey="Samieri, Cecilia" sort="Samieri, Cecilia" uniqKey="Samieri C" first="Cecilia" last="Samieri">Cecilia Samieri</name></author><author><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name></author><author><name sortKey="Steffen, Lyn M" sort="Steffen, Lyn M" uniqKey="Steffen L" first="Lyn M." last="Steffen">Lyn M. Steffen</name></author><author><name sortKey="Steffen, Brian T" sort="Steffen, Brian T" uniqKey="Steffen B" first="Brian T." last="Steffen">Brian T. Steffen</name></author><author><name sortKey="Tsai, Michael Y" sort="Tsai, Michael Y" uniqKey="Tsai M" first="Michael Y." last="Tsai">Michael Y. Tsai</name></author><author><name sortKey="Van Dam, Rob M" sort="Van Dam, Rob M" uniqKey="Van Dam R" first="Rob M." last="Van Dam">Rob M. Van Dam</name></author><author><name sortKey="Voutilainen, Sari" sort="Voutilainen, Sari" uniqKey="Voutilainen S" first="Sari" last="Voutilainen">Sari Voutilainen</name></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></author><author><name sortKey="Mozaffarian, Dariush" sort="Mozaffarian, Dariush" uniqKey="Mozaffarian D" first="Dariush" last="Mozaffarian">Dariush Mozaffarian</name></author></analytic><series><title level="j">JAMA internal medicine</title><idno type="ISSN">2168-6106</idno><idno type="eISSN">2168-6114</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>IMPORTANCE</title><p id="P1">The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers.</p></sec><sec id="S2"><title>OBJECTIVE</title><p id="P2">To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5ω-3), docosapentaenoic acid (DPA; 22:5ω-3), and docosahexaenoic acid (DHA; 22:6ω-3) and plant-derived α-linolenic acid (ALA; 18:3ω-3) for incident CHD.</p></sec><sec id="S3"><title>DATA SOURCES</title><p id="P3">A global consortium of 19 studies identified by November 2014.</p></sec><sec id="S4"><title>STUDY SELECTION</title><p id="P4">Available prospective (cohort, nested case-control) or retrospective studies with circulating or tissue ω-3 biomarkers and ascertained CHD.</p></sec><sec id="S5"><title>DATA EXTRACTION AND SYNTHESIS</title><p id="P5">Each study conducted standardized, individual-level analysis using harmonized models, exposures, outcomes, and covariates. Findings were centrally pooled using random-effects meta-analysis. Heterogeneity was examined by age, sex, race, diabetes, statins, aspirin, ω-6 levels, and <italic>FADS</italic> desaturase genes.</p></sec><sec id="S6"><title>MAIN OUTCOMES AND MEASURES</title><p id="P6">le;&-1qIncident total CHD, fatal CHD, and nonfatal myocardial infarction (MI).</p></sec><sec id="S7"><title>RESULTS</title><p id="P7">The 19 studies comprised 16 countries, 45 637 unique individuals, and 7973 total CHD, 2781 fatal CHD, and 7157 nonfatal MI events, with ω-3 measures in total plasma, phospholipids, cholesterol esters, and adipose tissue. Median age at baseline was 59 years (range, 18–97 years), and 28 660 (62.8%) were male. In continuous (per 1-SD increase) multivariable-adjusted analyses, the ω-3 biomarkers ALA, DPA, and DHA were associated with a lower risk of fatal CHD, with relative risks (RRs) of 0.91 (95% CI, 0.84–0.98) for ALA, 0.90 (95% CI, 0.85–0.96) for DPA, and 0.90 (95% CI, 0.84–0.96) for DHA. Although DPA was associated with a lower risk of total CHD (RR, 0.94; 95% CI, 0.90–0.99), ALA (RR, 1.00; 95% CI, 0.95–1.05), EPA (RR, 0.94; 95% CI, 0.87–1.02), and DHA (RR, 0.95; 95% CI, 0.91–1.00)were not. Significant associations with nonfatal MI were not evident per 1 SD. Across quintiles, lower risk of nonfatal MI was evident with EPA (RR, 0.71; 95% CI, 0.56–0.90) and ALA (RR, 0.87; 95% CI, 0.78–0.97), and lower risk of fatal CHD was evident with DPA (RR, 0.76; 95% CI, 0.65–0.90) and DHA (RR, 0.77; 95% CI, 0.64–0.89). Associations appeared generally stronger in phospholipids and total plasma. Restricted cubic splines did not identify evidence of nonlinearity in dose responses.</p></sec><sec id="S8"><title>CONCLUSIONS AND RELEVANCE</title><p id="P8">On the basis of available studies of free-living populations globally, biomarker concentrations of seafood and plant-derived ω-3 fatty acids are associated with a lower incidence of fatal CHD.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aslibekyan, Stella" sort="Aslibekyan, Stella" uniqKey="Aslibekyan S" first="Stella" last="Aslibekyan">Stella Aslibekyan</name><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><name sortKey="Campos, Hannia" sort="Campos, Hannia" uniqKey="Campos H" first="Hannia" last="Campos">Hannia Campos</name><name sortKey="Chaves, Paulo H M" sort="Chaves, Paulo H M" uniqKey="Chaves P" first="Paulo H. M." last="Chaves">Paulo H. M. Chaves</name><name sortKey="Chiuve, Stephanie E" sort="Chiuve, Stephanie E" uniqKey="Chiuve S" first="Stephanie E." last="Chiuve">Stephanie E. Chiuve</name><name sortKey="Del Gobbo, Liana C" sort="Del Gobbo, Liana C" uniqKey="Del Gobbo L" first="Liana C." last="Del Gobbo">Liana C. Del Gobbo</name><name sortKey="Dela Cruz, Luicito" sort="Dela Cruz, Luicito" uniqKey="Dela Cruz L" first="Luicito" last="Dela Cruz">Luicito Dela Cruz</name><name sortKey="Djousse, Luc" sort="Djousse, Luc" uniqKey="Djousse L" first="Luc" last="Djoussé">Luc Djoussé</name><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name><name sortKey="Frazier Wood, Alexis C" sort="Frazier Wood, Alexis C" uniqKey="Frazier Wood A" first="Alexis C." last="Frazier-Wood">Alexis C. Frazier-Wood</name><name sortKey="Fretts, Amanda M" sort="Fretts, Amanda M" uniqKey="Fretts A" first="Amanda M." last="Fretts">Amanda M. Fretts</name><name sortKey="G Mez Aracena, Jose" sort="G Mez Aracena, Jose" uniqKey="G Mez Aracena J" first="Jose" last="G Mez-Aracena">Jose G Mez-Aracena</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Guallar, Eliseo" sort="Guallar, Eliseo" uniqKey="Guallar E" first="Eliseo" last="Guallar">Eliseo Guallar</name><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><name sortKey="Hodge, Allison M" sort="Hodge, Allison M" uniqKey="Hodge A" first="Allison M." last="Hodge">Allison M. Hodge</name><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><name sortKey="Imamura, Fumiaki" sort="Imamura, Fumiaki" uniqKey="Imamura F" first="Fumiaki" last="Imamura">Fumiaki Imamura</name><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><name sortKey="Jansson, Jan H Kan" sort="Jansson, Jan H Kan" uniqKey="Jansson J" first="Jan-H Kan" last="Jansson">Jan-H Kan Jansson</name><name sortKey="Johansson, Ingegerd" sort="Johansson, Ingegerd" uniqKey="Johansson I" first="Ingegerd" last="Johansson">Ingegerd Johansson</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Koh, Woon Puay" sort="Koh, Woon Puay" uniqKey="Koh W" first="Woon-Puay" last="Koh">Woon-Puay Koh</name><name sortKey="Lemaitre, Rozenn N" sort="Lemaitre, Rozenn N" uniqKey="Lemaitre R" first="Rozenn N." last="Lemaitre">Rozenn N. Lemaitre</name><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name><name sortKey="Marklund, Matti" sort="Marklund, Matti" uniqKey="Marklund M" first="Matti" last="Marklund">Matti Marklund</name><name sortKey="Matsumoto, Chisa" sort="Matsumoto, Chisa" uniqKey="Matsumoto C" first="Chisa" last="Matsumoto">Chisa Matsumoto</name><name sortKey="Mozaffarian, Dariush" sort="Mozaffarian, Dariush" uniqKey="Mozaffarian D" first="Dariush" last="Mozaffarian">Dariush Mozaffarian</name><name sortKey="Prem, Kiesha" sort="Prem, Kiesha" uniqKey="Prem K" first="Kiesha" last="Prem">Kiesha Prem</name><name sortKey="Rimm, Eric B" sort="Rimm, Eric B" uniqKey="Rimm E" first="Eric B." last="Rimm">Eric B. Rimm</name><name sortKey="Riserus, Ulf" sort="Riserus, Ulf" uniqKey="Riserus U" first="Ulf" last="Risérus">Ulf Risérus</name><name sortKey="Samieri, Cecilia" sort="Samieri, Cecilia" uniqKey="Samieri C" first="Cecilia" last="Samieri">Cecilia Samieri</name><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><name sortKey="Steffen, Brian T" sort="Steffen, Brian T" uniqKey="Steffen B" first="Brian T." last="Steffen">Brian T. Steffen</name><name sortKey="Steffen, Lyn M" sort="Steffen, Lyn M" uniqKey="Steffen L" first="Lyn M." last="Steffen">Lyn M. Steffen</name><name sortKey="Tanaka, Tosh" sort="Tanaka, Tosh" uniqKey="Tanaka T" first="Tosh" last="Tanaka">Tosh Tanaka</name><name sortKey="Tsai, Michael Y" sort="Tsai, Michael Y" uniqKey="Tsai M" first="Michael Y." last="Tsai">Michael Y. Tsai</name><name sortKey="Van Dam, Rob M" sort="Van Dam, Rob M" uniqKey="Van Dam R" first="Rob M." last="Van Dam">Rob M. Van Dam</name><name sortKey="Virtanen, Jyrki K" sort="Virtanen, Jyrki K" uniqKey="Virtanen J" first="Jyrki K." last="Virtanen">Jyrki K. Virtanen</name><name sortKey="Voutilainen, Sari" sort="Voutilainen, Sari" uniqKey="Voutilainen S" first="Sari" last="Voutilainen">Sari Voutilainen</name><name sortKey="Wennberg, Maria" sort="Wennberg, Maria" uniqKey="Wennberg M" first="Maria" last="Wennberg">Maria Wennberg</name><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><name sortKey="Wu, Jason H Y" sort="Wu, Jason H Y" uniqKey="Wu J" first="Jason H. Y." last="Wu">Jason H. Y. Wu</name><name sortKey="Yakoob, Mohammad Y" sort="Yakoob, Mohammad Y" uniqKey="Yakoob M" first="Mohammad Y." last="Yakoob">Mohammad Y. Yakoob</name><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><name sortKey="Zhou, Xia" sort="Zhou, Xia" uniqKey="Zhou X" first="Xia" last="Zhou">Xia Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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